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Table 1 Differential expression of genes

From: Transcription networks responsible for early regulation of Salmonella-induced inflammation in the jejunum of pigs

GENE

Ratio Salm/Mock 8 h

Ratio 2 h

Ratio 4 h

Description

Pig 2

Pig 3

Pig 4

2/3

2/4

3/4

2/3

2/4

3/4

# Genes

325

37

164

79

104

132

142

49

202

 

NFKBIA (PCR)

7.8

-

5.6

0.04

0.07

-

-

-

7.2

Nuclear factor-kappaB inhibitor alpha

IL8 (PCR)

13.1

-

8.2

0.03

0.03

-

10.7

4.1

-

Interleukin-8

REG3A (PCR)

49.8

-

11.5

0.09

0.01

0.03

14.1

-

0.07

Islet of Langerhans regenerating protein 3A (alias; PAP)

TIMP1 (PCR)

13.1

-

4.7

-

0.22

-

8.2

-

0.23

Metalloproteinase inhibitor 1 precursor (TIMP-1)

IL1B (PCR)

37.7

3.9

47.5

0.17

-

-

25.9

-

0.06

Interleukin-1 beta

MMP1 (PCR)

10.2

3.4

3.7

0.15

-

-

13.1

-

-

Matrix metalloproteinase-1 (Interstitial collagenase)

S100A9

22.6

5.4

4.9

-

-

-

18.1

8.5

-

S100 calcium binding protein A9 (calgranulin B)

HSD11B2

0.56

0.14

0.34

-

-

-

-

-

-

Hydroxysteroid 11-beta dehydrogenase 2

TFF2

0.40

0.08

0.56

-

-

-

-

0.13

-

Trefoil factor 2 (Pancreatic spasmolytic polypeptide)

HSPA1B

1.15

10.4

0.87

-

-

-

-

-

-

Heat shock 70 kDa protein 1B

HSPA1A

0.86

6.2

0.95

-

-

-

-

-

-

Heat shock 70 kDa protein 1A

RAC1

0.71

0.08

1.3

-

-

-

-

-

-

Ras-related C3 botulinum toxin substrate 1

TNFRSF12A

2.1

8.5

2.7

-

-

-

-

-

-

TNF receptor superfamily member Fn14

NR4A1

1.9

7.2

3.0

-

0.21

-

-

-

-

Nuclear receptor subfamily 4, group A, member 1

IRF1

6.4

6.4

4.1

-

-

-

-

-

-

Interferon regulatory factor 1

EGR1

4.6

5.6

4.8

-

0.15

-

5.8

9.7

-

Early growth response 1

THBS1

14.1

9.7

4.8

-

-

-

8.3

-

0.15

Thrombospondin 1

F3

2.0

3.1

5.3

0.24

-

-

-

-

-

Coagulation factor III

FOS

3.3

4.2

8.0

0.20

0.17

-

7.9

6.6

-

c-Fos protein

DMBT1

8.9

6.9

8.2

-

0.08

-

-

-

0.09

Surfactant pulmonary-associated D-binding protein (gp-340)

PLAUR

10.5

8.6

11.8

-

-

-

-

-

-

Urokinase plasminogen activator surface receptor

CYR61

11.2

18.1

36.0

-

-

-

-

4.9

-

cysteine-rich, angiogenic inducer 61

IL1RN

70.2

3.2

73.2

-

-

-

-

-

-

Interleukin-1 receptor antagonist protein

  1. # Genes: Total number of differentially expressed genes with a ratio of 3-fold up- or down-regulated detected in 8 hours isogenic comparisons (Salmonella over mock, left panel), and in 2 (middle panel) or 4 (right panel) hours inter-animal comparisons. In this table only the 19 genes were listed that showed a significant association in the STITCH network (see Figure 3) generated from the 8 hours isogenic comparison of Salmonella versus mock treated segments of pig 3. (_); non-significant ratio’s (<3 and >0.33) for above mentioned 19 genes extracted from micro array data files. In addition, ratios of differential expression measured in micro array experiments for all genes analyzed with QRT-PCR were listed (PCR). All genes showing a ratio of more than 3-fold up or down in both isogenic and inter-animal comparisons are presented in Additional file 1: Table S1.
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