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Table 1 Differential expression of genes

From: Transcription networks responsible for early regulation of Salmonella-induced inflammation in the jejunum of pigs

GENE Ratio Salm/Mock 8 h Ratio 2 h Ratio 4 h Description
Pig 2 Pig 3 Pig 4 2/3 2/4 3/4 2/3 2/4 3/4
# Genes 325 37 164 79 104 132 142 49 202  
NFKBIA (PCR) 7.8 - 5.6 0.04 0.07 - - - 7.2 Nuclear factor-kappaB inhibitor alpha
IL8 (PCR) 13.1 - 8.2 0.03 0.03 - 10.7 4.1 - Interleukin-8
REG3A (PCR) 49.8 - 11.5 0.09 0.01 0.03 14.1 - 0.07 Islet of Langerhans regenerating protein 3A (alias; PAP)
TIMP1 (PCR) 13.1 - 4.7 - 0.22 - 8.2 - 0.23 Metalloproteinase inhibitor 1 precursor (TIMP-1)
IL1B (PCR) 37.7 3.9 47.5 0.17 - - 25.9 - 0.06 Interleukin-1 beta
MMP1 (PCR) 10.2 3.4 3.7 0.15 - - 13.1 - - Matrix metalloproteinase-1 (Interstitial collagenase)
S100A9 22.6 5.4 4.9 - - - 18.1 8.5 - S100 calcium binding protein A9 (calgranulin B)
HSD11B2 0.56 0.14 0.34 - - - - - - Hydroxysteroid 11-beta dehydrogenase 2
TFF2 0.40 0.08 0.56 - - - - 0.13 - Trefoil factor 2 (Pancreatic spasmolytic polypeptide)
HSPA1B 1.15 10.4 0.87 - - - - - - Heat shock 70 kDa protein 1B
HSPA1A 0.86 6.2 0.95 - - - - - - Heat shock 70 kDa protein 1A
RAC1 0.71 0.08 1.3 - - - - - - Ras-related C3 botulinum toxin substrate 1
TNFRSF12A 2.1 8.5 2.7 - - - - - - TNF receptor superfamily member Fn14
NR4A1 1.9 7.2 3.0 - 0.21 - - - - Nuclear receptor subfamily 4, group A, member 1
IRF1 6.4 6.4 4.1 - - - - - - Interferon regulatory factor 1
EGR1 4.6 5.6 4.8 - 0.15 - 5.8 9.7 - Early growth response 1
THBS1 14.1 9.7 4.8 - - - 8.3 - 0.15 Thrombospondin 1
F3 2.0 3.1 5.3 0.24 - - - - - Coagulation factor III
FOS 3.3 4.2 8.0 0.20 0.17 - 7.9 6.6 - c-Fos protein
DMBT1 8.9 6.9 8.2 - 0.08 - - - 0.09 Surfactant pulmonary-associated D-binding protein (gp-340)
PLAUR 10.5 8.6 11.8 - - - - - - Urokinase plasminogen activator surface receptor
CYR61 11.2 18.1 36.0 - - - - 4.9 - cysteine-rich, angiogenic inducer 61
IL1RN 70.2 3.2 73.2 - - - - - - Interleukin-1 receptor antagonist protein
  1. # Genes: Total number of differentially expressed genes with a ratio of 3-fold up- or down-regulated detected in 8 hours isogenic comparisons (Salmonella over mock, left panel), and in 2 (middle panel) or 4 (right panel) hours inter-animal comparisons. In this table only the 19 genes were listed that showed a significant association in the STITCH network (see Figure 3) generated from the 8 hours isogenic comparison of Salmonella versus mock treated segments of pig 3. (_); non-significant ratio’s (<3 and >0.33) for above mentioned 19 genes extracted from micro array data files. In addition, ratios of differential expression measured in micro array experiments for all genes analyzed with QRT-PCR were listed (PCR). All genes showing a ratio of more than 3-fold up or down in both isogenic and inter-animal comparisons are presented in Additional file 1: Table S1.