Figure 5

Impact of 1F7 mAb on TLR and NOD agonist-induced IL-10 production by monocytes. Peripheral blood monocytes obtained from 10 healthy donors were unstimulated (NT) or stimulated with either 100 ng/ml LPS or 2.5 μg/ml PGN for 3 days in the presence of 1.92 μg/ml 1F7 mAb or IgMκ control mAb. Supernatant IL-10 concentration was then measured. All data shown represent mean values ± SE and significant differences between 1F7 mAb-treated and IgMκ control mAb-treated monocytes are noted (*p < 0.05).