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Table 1 Effects of XH-14 on LPS-induced mRNA expression of iNOS, COX-2, IL-1β and IL-6 in RAW 264.7 cells 1

From: XH-14, a novel danshen methoxybenzo[b]furan derivative, exhibits anti-inflammatory properties in lipopolysaccharide-treated RAW 264.7 cells

   mRNA iNOS COX-2 IL-1β IL-6
(relative expression)
   vehicle NDa ND ND ND
     LPS 1.00 ± 0.00 1.00 ± 0.00 1.00 ± 0.00 1.00 ± 0.00
LPS + 1 μM XH-14 1.14 ± 0.21 0.80 ± 0.23 0.90 ± 0.02 0.74 ± 0.27
LPS + 5 μM XH-14 0.79 ± 0.12** 0.69 ± 0.25 0.45 ± 0.06*** 0.75 ± 0.11**
LPS + 20 μM XH-14 0.65 ± 0.03*** 0.71 ± 0.01*** 0.37 ± 0.03*** 0.59 ± 0.05***
  1. 1LPS-stimulated RAW 264.7 cells were cultured with 0–20 μM XH-14 in the presence or absence for 6 h and gene expression was quantified by real-time RT-PCR. The results are reported as mean ± SEM of three independent experiments in triplicate. Statistical significance is based on the difference when compared with LPS-stimulated cells (**P < 0.01, ***P < 0.001).
  2. a ND; Not detected.