Table 2 LPS/IFN-γ driven macrophage expression of CD40 and CD86 is modulated by IL-12p40 siRNA.
From: Efficient delivery of small interfering RNA for inhibition of IL-12p40 expression in vivo
Treatment | Mean Fluorescent Intensity (+/-SEM) | |||||
|---|---|---|---|---|---|---|
LPS/IFN-γ | siRNA | CD40 | CD86 | CD80 | CD14 | MHCII |
- | - | 22 (5) | 9 (4) | 34 (8) | 44 (11) | 19 (8) |
- | IL-12p40 | 16 (9) | 14 (1) | 29 (2) | 49 (4) | 18 (8) |
+ | - | 290 (27) | 41(5) | 102 (21) | 86 (11) | 46 (5) |
+ | IL-12p40 | 94 (17)* | 7 (1)* | 66 (13) | 47 (9) | 46 (5) |
+ | Mut.siRNA | 241 (18) | 72 (6) | 102 (4) | 86 (16) | 43 (5) |