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Table 2 LPS/IFN-γ driven macrophage expression of CD40 and CD86 is modulated by IL-12p40 siRNA.

From: Efficient delivery of small interfering RNA for inhibition of IL-12p40 expression in vivo

Treatment Mean Fluorescent Intensity (+/-SEM)
LPS/IFN-γ siRNA CD40 CD86 CD80 CD14 MHCII
- - 22 (5) 9 (4) 34 (8) 44 (11) 19 (8)
- IL-12p40 16 (9) 14 (1) 29 (2) 49 (4) 18 (8)
+ - 290 (27) 41(5) 102 (21) 86 (11) 46 (5)
+ IL-12p40 94 (17)* 7 (1)* 66 (13) 47 (9) 46 (5)
+ Mut.siRNA 241 (18) 72 (6) 102 (4) 86 (16) 43 (5)
  1. Data are the mean ± SEM to nearest whole number of MFI of 3 independent experiments, each performed in triplicate (n = 3), * statistical significance (α = 0.05) compared to cells stimulated with LPS/IFN-γ in the absence of IL-12p40 siRNA.