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Table 1 AT1 as a key inductor of inflammation and disease. A wide range of pro-inflammatory mediators, cytokines, chemokines and surface adhesion moleculesinvolved in a number of diseases are induced by AT1 and thus inhibited by its blockade.

From: Cancer, inflammation and the AT1 and AT2 receptors

Disease

Mediators inhibited by AT1 blockade

Reference

Cardiovascular disease

NFκB, 'markers of oxidation inflammation and fibrinolysis'

66

Cardiovascular disease

TGF-β

67

Cardiovascular disease

TNF-α, IL-6, ICAM-1, VCAM-1

18

Cardiovascular disease

PAI-1

19

Cardiovascular disease

Surface adhesion molecules

68,69

Cardiovascular disease

MCP in Hypercholesterolemia associated endothelial dysfunction

70

Kidney disease

None noted in this study.

71

Pancreatitis

(Key markers of the disease)

72

Liver fibrosis and cirrhosis

'TGF-β and pro-inflammatory cytokines'

21

Skin disease

None noted in this study.

73

Osteoporosis

'Markers of inflammation'

74

Alzheimer's, Huntington's and Parkinson's

(TGF-β [75], over expression of AT1 and AT2 noted in affected brain areas)

75–78