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Table 1 AT1 as a key inductor of inflammation and disease. A wide range of pro-inflammatory mediators, cytokines, chemokines and surface adhesion moleculesinvolved in a number of diseases are induced by AT1 and thus inhibited by its blockade.

From: Cancer, inflammation and the AT1 and AT2 receptors

Disease Mediators inhibited by AT1 blockade Reference
Cardiovascular disease NFκB, 'markers of oxidation inflammation and fibrinolysis' 66
Cardiovascular disease TGF-β 67
Cardiovascular disease TNF-α, IL-6, ICAM-1, VCAM-1 18
Cardiovascular disease PAI-1 19
Cardiovascular disease Surface adhesion molecules 68,69
Cardiovascular disease MCP in Hypercholesterolemia associated endothelial dysfunction 70
Kidney disease None noted in this study. 71
Pancreatitis (Key markers of the disease) 72
Liver fibrosis and cirrhosis 'TGF-β and pro-inflammatory cytokines' 21
Skin disease None noted in this study. 73
Osteoporosis 'Markers of inflammation' 74
Alzheimer's, Huntington's and Parkinson's (TGF-β [75], over expression of AT1 and AT2 noted in affected brain areas) 75–78