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  1. Research

    Abnormal cannabidiol attenuates experimental colitis in mice, promotes wound healing and inhibits neutrophil recruitment

    Non-psychotropic atypical cannabinoids have therapeutic potential in a variety of inflammatory conditions including those of the gastrointestinal tract. Here we examined the effects of the atypical cannabinoid...

    Regina M. Krohn, Sean A. Parsons, Jakub Fichna, Kamala D. Patel, Robin M. Yates, Keith A. Sharkey and Martin A. Storr

    Journal of Inflammation 2016 13:21

    Published on: 14 July 2016

  2. Research

    A human and animal model-based approach to investigating the anti-inflammatory profile and potential of the 5-HT2B receptor antagonist AM1030

    Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by highly pruritic eczematous lesions that are commonly treated with topical corticosteroids and calcineurin inhibitors. Side-effects...

    Niklas Palmqvist, Max Siller, Cecilia Klint and Anders Sjödin

    Journal of Inflammation 2016 13:20

    Published on: 22 June 2016

  3. Research

    Transforming growth factor beta 1 induced endothelin-1 release is peroxisome proliferator-activated receptor gamma dependent in A549 cells

    Endothelin-1 (ET-1) is involved in pulmonary vascular remodeling. The aim of this study was to investigate the biochemical interactions between PPAR-γ, TGF-β1 and ET-1 in vitro.

    Shulin Xiang, Yi Zeng, Bin Xiong, Yueqiu Qin, Xia Huang, Yujie Jiang, Weigui Luo, Suren R. Sooranna and Liao Pinhu

    Journal of Inflammation 2016 13:19

    Published on: 10 June 2016

  4. Research

    Effects of CpG Oligodeoxynucleotide 1826 on transforming growth factor-beta 1 and radiation-induced pulmonary fibrosis in mice

    Cytosine-phosphate-guanine (CpG) oligodeoxyribonucleotides (ODNs) are synthetic DNA fragments containing unmethylated cytosine-guanine motifs with potential immune modulatory effects and have recently been sug...

    Xuan Li, Guoxiong Xu, Tiankui Qiao, Sujuan Yuan, Xibing Zhuang, Jihong Zhang and Hui Bin Sun

    Journal of Inflammation 2016 13:16

    Published on: 17 May 2016

  5. Research

    The synthetic cannabinoid WIN55,212-2 mesylate decreases the production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts by activating CB2, TRPV1, TRPA1 and yet unidentified receptor targets

    In rheumatoid arthritis (RA), synovial fibroblasts (SF) secrete large amounts of IL-6, IL-8 and matrix metalloproteinases (MMPs) which are crucial for cartilage destruction. RASFs are sensitive to the action o...

    Torsten Lowin, Georg Pongratz and Rainer H. Straub

    Journal of Inflammation 2016 13:15

    Published on: 5 May 2016

  6. Research

    The effect of high glucose on the inhibitory action of C21, a selective AT2R agonist, of LPS-stimulated tissue factor expression in human mononuclear cells

    Intimate links connect tissue factor (TF), the principal initiator of the clotting cascade, to inflammation, a cross-talk amplified by locally generated Angiotensin (AT) II, the effector arm of the Renin Angio...

    Cristina Balia, Valentina Scalise, Silvana Cianchetti, Francesca Faita, Tommaso Neri, Vittoria Carnicelli, Riccardo Zucchi, Alessandro Celi and Roberto Pedrinelli

    Journal of Inflammation 2016 13:14

    Published on: 4 May 2016

  7. Research

    The association between blood glucose levels and matrix-metalloproteinase-9 in early severe sepsis and septic shock

    Hyperglycemia is a frequent and important metabolic derangement that accompanies severe sepsis and septic shock. Matrix-Metalloproteinase 9 (MMP-9) has been shown to be elevated in acute stress hyperglycemia, ...

    Gul R. Sachwani, Anja K. Jaehne, Namita Jayaprakash, Mark Kuzich, Violet Onkoba, Dione Blyden and Emanuel P. Rivers

    Journal of Inflammation 2016 13:13

    Published on: 22 April 2016

  8. Research

    Characterizing heterogeneity in the response of synovial mesenchymal progenitor cells to synovial macrophages in normal individuals and patients with osteoarthritis

    Resident macrophages in OA synovial tissue contribute to synovitis through pro-inflammatory mediators driving cartilage loss. What remains unknown is how these macrophages interact with synovial mesenchymal pr...

    Akash Fichadiya, Karri L Bertram, Guomin Ren, Robin M Yates and Roman J Krawetz

    Journal of Inflammation 2016 13:12

    Published on: 6 April 2016

  9. Review

    Pathogenesis of eosinophilic chronic rhinosinusitis

    Eosinophilic chronic rhinosinusitis (ECRS) is considered a refractory and intractable disease. Patients with ECRS present with thick mucus production, long-term nasal congestion, loss of sense of smell, and in...

    Said Ahmad Shah, Hajime Ishinaga and Kazuhiko Takeuchi

    Journal of Inflammation 2016 13:11

    Published on: 6 April 2016

  10. Research

    Hydrogen sulfide modulates chromatin remodeling and inflammatory mediator production in response to endotoxin, but does not play a role in the development of endotoxin tolerance

    Pretreatment with low doses of LPS (lipopolysaccharide, bacterial endotoxin) reduces the pro-inflammatory response to a subsequent higher LPS dose, a phenomenon known as endotoxin tolerance. Moreover, hydrogen...

    Ester C. S. Rios, Francisco G. Soriano, Gabor Olah, Domokos Gerö, Bartosz Szczesny and Csaba Szabo

    Journal of Inflammation 2016 13:10

    Published on: 1 April 2016

  11. Research

    Interleukin-1beta-induced reduction of tissue water diffusion in the juvenile rat brain on ADC MRI is not associated with 31P MRS-detectable energy failure

    It has long been known that an intrastriatal microinjection of the archetypal pro-inflammatory cytokine, interleukin-1beta (IL-1β), in juvenile rats induces a chronic reduction in the apparent diffusion coeffi...

    Raman Saggu

    Journal of Inflammation 2016 13:9

    Published on: 17 March 2016

    The Erratum to this article has been published in Journal of Inflammation 2016 13:17

  12. Short report

    Mycobacterium leprae alters classical activation of human monocytes in vitro

    Macrophages play a central role in the pathogenesis of leprosy, caused by Mycobacterium leprae. The polarized clinical presentations in leprosy are associated with differential immune activation. In tuberculoid l...

    Dorothy Fallows, Blas Peixoto, Gilla Kaplan and Claudia Manca

    Journal of Inflammation 2016 13:8

    Published on: 11 March 2016

  13. Research

    Lipopolysaccharide-induced inflammation or unilateral ureteral obstruction yielded multiple types of glycosylated Lipocalin 2

    The amount of urinary glycoprotein lipocalin 2 (LCN2) has been known to increase after kidney injury because of failed reabsorption by the proximal tubules or direct secretion from injured tissues. However, th...

    Yoko Fujiwara, Hiroyoshi Tsuchiya, Nobuya Sakai, Katsushi Shibata, Akio Fujimura and Taka-aki Koshimizu

    Journal of Inflammation 2016 13:7

    Published on: 5 March 2016

  14. Research

    ERK2 and Akt are negative regulators of insulin and Tumor Necrosis Factor-α stimulated VCAM-1 expression in rat aorta endothelial cells

    Diabetes is quickly becoming the most widespread disorder in the Western world. Among the most prevalent effects of diabetes is atherosclerosis, which in turn is driven in part by inflammation. Both insulin an...

    Gregory B. Pott, Mark Tsurudome, Nadia Bamfo and Marc L. Goalstone

    Journal of Inflammation 2016 13:6

    Published on: 25 February 2016

  15. Short report

    Role of goblet cell protein CLCA1 in murine DSS colitis

    The secreted goblet cell protein CLCA1 (chloride channel regulator, calcium-activated-1) is, in addition to its established role in epithelial chloride conductance regulation, thought to act as a multifunction...

    Nancy A. Erickson, Lars Mundhenk, Samoa Giovannini, Rainer Glauben, Markus M. Heimesaat and Achim D. Gruber

    Journal of Inflammation 2016 13:5

    Published on: 4 February 2016

  16. Short report

    Nur77-mediated TRAF6 signalling protects against LPS-induced sepsis in mice

    Nur77, a key member of the NR4A receptor subfamily, is involved in the regulation of inflammation and immunity. However, the in vivo regulatory roles of Nur77 in sepsis and the mechanisms involved remains larg...

    Xiu-Ming Li, Shen Zhang, Xiao-Shun He, Peng-Da Guo, Xing-Xing Lu, Jing-Ru Wang, Jian-Ming Li and Hua Wu

    Journal of Inflammation 2016 13:4

    Published on: 2 February 2016

  17. Research

    Non-unions treated with bone morphogenic protein 7: introducing the quantitative measurement of human serum cytokine levels as promising tool in evaluation of adjunct non-union therapy

    In this study we sought to determine if application of bone morphogenic protein 7 (BMP-7) promotes physiological bone healing of non-unions and to investigate if serum cytokine analysis may serve as a promisin...

    Arash Moghaddam, Lisa Breier, Patrick Haubruck, Daniel Bender, Bahram Biglari, Andreas Wentzensen and Gerald Zimmermann

    Journal of Inflammation 2016 13:3

    Published on: 22 January 2016

  18. Review

    CXCL14 as an emerging immune and inflammatory modulator

    CXCL14, a relatively novel chemokine, is a non-ELR (glutamic acid-leucine-arginine) chemokine with a broad spectrum of biological activities. CXCL14 mainly contributes to the regulation of immune cell migratio...

    Jing Lu, Mita Chatterjee, Hannes Schmid, Sandra Beck and Meinrad Gawaz

    Journal of Inflammation 2016 13:1

    Published on: 5 January 2016

  19. Research

    The prognostic influence of tumor infiltrating Foxp3+CD4+, CD4+ and CD8+ T cells in resected non-small cell lung cancer

    Different subsets of tumor infiltrating T lymphocytes are believed to play essential role in the immune response to cancer cells. The data of these cells in NSCLC are relatively rare and controversial therefor...

    Jurgita Jackute, Marius Zemaitis, Darius Pranys, Brigita Sitkauskiene, Skaidrius Miliauskas, Vytis Bajoriunas, Simona Lavinskiene and Raimundas Sakalauskas

    Journal of Inflammation 2015 12:63

    Published on: 23 November 2015

  20. Research

    CFTR Knockdown induces proinflammatory changes in intestinal epithelial cells

    Hyperinflammation is a hallmark feature of cystic fibrosis (CF) airways. However, inflammation has also been documented systemically and, more recently, in extrapulmonary CF-affected tissues such as the pancre...

    Karoline St-Martin Crites, Geneviève Morin, Valérie Orlando, Natacha Patey, Catherine Cantin, Judith Martel, Emmanuelle Brochiero and Geneviève Mailhot

    Journal of Inflammation 2015 12:62

    Published on: 7 November 2015

  21. Research

    E-selectin and vascular cell adhesion molecule-1 as biomarkers of 3-month outcome in cerebrovascular diseases

    Inflammation is known to worsen cerebral damage at the acute phase of stroke. In this setting, cell adhesion molecules (CAMs) play a crucial role mediating migration of immune cells into the infarcted area. Ho...

    Sébastien Richard, Linnéa Lagerstedt, Pierre R. Burkhard, Marc Debouverie, Natacha Turck and Jean-Charles Sanchez

    Journal of Inflammation 2015 12:61

    Published on: 4 November 2015

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Affiliated with the British Inflammation Research Association (BIRAs).