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  1. Research

    Acidification changes affect the inflammasome in human nucleus pulposus cells

    Interleukin (IL)-1β is involved in the pathology of intervertebral disc degeneration. Under normal conditions, IL-1β is present in cells in an inactive form (pro-IL-1β). However, under pathological conditions,...

    Frank J. Brand III, Mahtab Forouzandeh, Harmanpreet Kaur, Francesco Travascio and Juan Pablo de Rivero Vaccari

    Journal of Inflammation 2016 13:29

    Published on: 24 August 2016

  2. Research

    Peroxisome proliferator-activated receptor (PPAR) α and δ activators induce ICAM-1 expression in quiescent non stimulated endothelial cells

    Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that are implicated in the regulation of lipid and glucose homeostasis. PPAR agonists have been shown to control i...

    Julia Naidenow, Igor Hrgovic, Monika Doll, Tsige Hailemariam-Jahn, Victoria Lang, Johannes Kleemann, Stefan Kippenberger, Roland Kaufmann, Nadja Zöller and Markus Meissner

    Journal of Inflammation 2016 13:27

    Published on: 20 August 2016

  3. Research

    Nasal inflammation and its response to local glucocorticoid regular treatment in patients with persistent non-allergic rhinitis: a pilot study

    The pathogenesis of non-allergic rhinitis (NAR) is still largely unknown. Furthermore, it is unclear whether there is a correlation between the effect of nasal glucocorticoids on nasal inflammation and on nasa...

    Donatella Poletti, Valeria Iannini, Paolo Casolari, Marco Contoli, Alberto Papi, Paul Kirkham, Trevor T. Hansel, Kian Fan Chung, Peter J. Barnes, Antonio Pastore, Stefano Pelucchi, Ian M. Adcock and Gaetano Caramori

    Journal of Inflammation 2016 13:26

    Published on: 4 August 2016

  4. Research

    Apolipoprotein A-I gene transfer exerts immunomodulatory effects and reduces vascular inflammation and fibrosis in ob/ob mice

    Obesity is associated with vascular inflammation, fibrosis and reduced high-density lipoproteins (HDL)-cholesterol. We aimed to investigate whether adenoviral gene transfer with human apolipoprotein (apo) A-I (Ad...

    Frank Spillmann, Bart De Geest, Ilayaraja Muthuramu, Ruhul Amin, Kapka Miteva, Burkert Pieske, Carsten Tschöpe and Sophie Van Linthout

    Journal of Inflammation 2016 13:25

    Published on: 2 August 2016

  5. Research

    A comparative study of blood endotoxin detection in haemodialysis patients

    Endotoxemia is commonly reported in patients receiving haemodialysis and implicated in the pathogenesis of systemic inflammation. The Limulus Amoebocyte Lysate (LAL) assay is the most commonly used blood endot...

    Jonathan Wong, Nathan Davies, Hasan Jeraj, Enric Vilar, Adie Viljoen and Ken Farrington

    Journal of Inflammation 2016 13:24

    Published on: 30 July 2016

  6. Research

    Abnormal cannabidiol attenuates experimental colitis in mice, promotes wound healing and inhibits neutrophil recruitment

    Non-psychotropic atypical cannabinoids have therapeutic potential in a variety of inflammatory conditions including those of the gastrointestinal tract. Here we examined the effects of the atypical cannabinoid...

    Regina M. Krohn, Sean A. Parsons, Jakub Fichna, Kamala D. Patel, Robin M. Yates, Keith A. Sharkey and Martin A. Storr

    Journal of Inflammation 2016 13:21

    Published on: 14 July 2016

  7. Research

    A human and animal model-based approach to investigating the anti-inflammatory profile and potential of the 5-HT2B receptor antagonist AM1030

    Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by highly pruritic eczematous lesions that are commonly treated with topical corticosteroids and calcineurin inhibitors. Side-effects...

    Niklas Palmqvist, Max Siller, Cecilia Klint and Anders Sjödin

    Journal of Inflammation 2016 13:20

    Published on: 22 June 2016

  8. Research

    Transforming growth factor beta 1 induced endothelin-1 release is peroxisome proliferator-activated receptor gamma dependent in A549 cells

    Endothelin-1 (ET-1) is involved in pulmonary vascular remodeling. The aim of this study was to investigate the biochemical interactions between PPAR-γ, TGF-β1 and ET-1 in vitro.

    Shulin Xiang, Yi Zeng, Bin Xiong, Yueqiu Qin, Xia Huang, Yujie Jiang, Weigui Luo, Suren R. Sooranna and Liao Pinhu

    Journal of Inflammation 2016 13:19

    Published on: 10 June 2016

  9. Research

    Effects of CpG Oligodeoxynucleotide 1826 on transforming growth factor-beta 1 and radiation-induced pulmonary fibrosis in mice

    Cytosine-phosphate-guanine (CpG) oligodeoxyribonucleotides (ODNs) are synthetic DNA fragments containing unmethylated cytosine-guanine motifs with potential immune modulatory effects and have recently been sug...

    Xuan Li, Guoxiong Xu, Tiankui Qiao, Sujuan Yuan, Xibing Zhuang, Jihong Zhang and Hui Bin Sun

    Journal of Inflammation 2016 13:16

    Published on: 17 May 2016

  10. Research

    The synthetic cannabinoid WIN55,212-2 mesylate decreases the production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts by activating CB2, TRPV1, TRPA1 and yet unidentified receptor targets

    In rheumatoid arthritis (RA), synovial fibroblasts (SF) secrete large amounts of IL-6, IL-8 and matrix metalloproteinases (MMPs) which are crucial for cartilage destruction. RASFs are sensitive to the action o...

    Torsten Lowin, Georg Pongratz and Rainer H. Straub

    Journal of Inflammation 2016 13:15

    Published on: 5 May 2016

  11. Research

    The effect of high glucose on the inhibitory action of C21, a selective AT2R agonist, of LPS-stimulated tissue factor expression in human mononuclear cells

    Intimate links connect tissue factor (TF), the principal initiator of the clotting cascade, to inflammation, a cross-talk amplified by locally generated Angiotensin (AT) II, the effector arm of the Renin Angio...

    Cristina Balia, Valentina Scalise, Silvana Cianchetti, Francesca Faita, Tommaso Neri, Vittoria Carnicelli, Riccardo Zucchi, Alessandro Celi and Roberto Pedrinelli

    Journal of Inflammation 2016 13:14

    Published on: 4 May 2016

  12. Research

    The association between blood glucose levels and matrix-metalloproteinase-9 in early severe sepsis and septic shock

    Hyperglycemia is a frequent and important metabolic derangement that accompanies severe sepsis and septic shock. Matrix-Metalloproteinase 9 (MMP-9) has been shown to be elevated in acute stress hyperglycemia, ...

    Gul R. Sachwani, Anja K. Jaehne, Namita Jayaprakash, Mark Kuzich, Violet Onkoba, Dione Blyden and Emanuel P. Rivers

    Journal of Inflammation 2016 13:13

    Published on: 22 April 2016

  13. Research

    Characterizing heterogeneity in the response of synovial mesenchymal progenitor cells to synovial macrophages in normal individuals and patients with osteoarthritis

    Resident macrophages in OA synovial tissue contribute to synovitis through pro-inflammatory mediators driving cartilage loss. What remains unknown is how these macrophages interact with synovial mesenchymal pr...

    Akash Fichadiya, Karri L Bertram, Guomin Ren, Robin M Yates and Roman J Krawetz

    Journal of Inflammation 2016 13:12

    Published on: 6 April 2016

  14. Review

    Pathogenesis of eosinophilic chronic rhinosinusitis

    Eosinophilic chronic rhinosinusitis (ECRS) is considered a refractory and intractable disease. Patients with ECRS present with thick mucus production, long-term nasal congestion, loss of sense of smell, and in...

    Said Ahmad Shah, Hajime Ishinaga and Kazuhiko Takeuchi

    Journal of Inflammation 2016 13:11

    Published on: 6 April 2016

  15. Research

    Hydrogen sulfide modulates chromatin remodeling and inflammatory mediator production in response to endotoxin, but does not play a role in the development of endotoxin tolerance

    Pretreatment with low doses of LPS (lipopolysaccharide, bacterial endotoxin) reduces the pro-inflammatory response to a subsequent higher LPS dose, a phenomenon known as endotoxin tolerance. Moreover, hydrogen...

    Ester C. S. Rios, Francisco G. Soriano, Gabor Olah, Domokos Gerö, Bartosz Szczesny and Csaba Szabo

    Journal of Inflammation 2016 13:10

    Published on: 1 April 2016

  16. Research

    Interleukin-1beta-induced reduction of tissue water diffusion in the juvenile rat brain on ADC MRI is not associated with 31P MRS-detectable energy failure

    It has long been known that an intrastriatal microinjection of the archetypal pro-inflammatory cytokine, interleukin-1beta (IL-1β), in juvenile rats induces a chronic reduction in the apparent diffusion coeffi...

    Raman Saggu

    Journal of Inflammation 2016 13:9

    Published on: 17 March 2016

    The Erratum to this article has been published in Journal of Inflammation 2016 13:17

  17. Short report

    Mycobacterium leprae alters classical activation of human monocytes in vitro

    Macrophages play a central role in the pathogenesis of leprosy, caused by Mycobacterium leprae. The polarized clinical presentations in leprosy are associated with differential immune activation. In tuberculoid l...

    Dorothy Fallows, Blas Peixoto, Gilla Kaplan and Claudia Manca

    Journal of Inflammation 2016 13:8

    Published on: 11 March 2016

  18. Research

    Lipopolysaccharide-induced inflammation or unilateral ureteral obstruction yielded multiple types of glycosylated Lipocalin 2

    The amount of urinary glycoprotein lipocalin 2 (LCN2) has been known to increase after kidney injury because of failed reabsorption by the proximal tubules or direct secretion from injured tissues. However, th...

    Yoko Fujiwara, Hiroyoshi Tsuchiya, Nobuya Sakai, Katsushi Shibata, Akio Fujimura and Taka-aki Koshimizu

    Journal of Inflammation 2016 13:7

    Published on: 5 March 2016

  19. Research

    ERK2 and Akt are negative regulators of insulin and Tumor Necrosis Factor-α stimulated VCAM-1 expression in rat aorta endothelial cells

    Diabetes is quickly becoming the most widespread disorder in the Western world. Among the most prevalent effects of diabetes is atherosclerosis, which in turn is driven in part by inflammation. Both insulin an...

    Gregory B. Pott, Mark Tsurudome, Nadia Bamfo and Marc L. Goalstone

    Journal of Inflammation 2016 13:6

    Published on: 25 February 2016

  20. Short report

    Role of goblet cell protein CLCA1 in murine DSS colitis

    The secreted goblet cell protein CLCA1 (chloride channel regulator, calcium-activated-1) is, in addition to its established role in epithelial chloride conductance regulation, thought to act as a multifunction...

    Nancy A. Erickson, Lars Mundhenk, Samoa Giovannini, Rainer Glauben, Markus M. Heimesaat and Achim D. Gruber

    Journal of Inflammation 2016 13:5

    Published on: 4 February 2016

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Affiliated with the British Inflammation Research Association (BIRAs).